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Systematic metabolic benefits In circulation, GLP-1 is primarily produced by intestinal L cells and pancreatic cells (its activity remains controversial), stimulated by the digestion of food or bile acids

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Supported by the substantial weight-loss efficacy of the GLP-1MK-801 conjugate and the potentiated hypothalamic changes in transcripts and proteins related to NMDA receptor-linked neuroplasticity, the alteration in MK-801 biodistribution governed by GLP-1-mediated targeting may effectively bypass the delivery of MK-801 to vagal afferent target neurons in the nucleus of the solitary tract

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Aviles-Olmos I., Dickson J., Kefalopoulou Z., Djamshidian A., Ell P., Soderlund T., et al

2014 Oct 1;124(10):447388