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This demonstrates a cognitive regulation of satiation, in which a feed-forward mechanism increases satiation before the initiation of a meal, eventually leading to meal termination (Fig

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Not surprisingly, a specific GLP-1 receptor antagonist, exendin [939] amide, accelerates gastric emptying in individuals without diabetes with proportional rises in plasma glucose and insulin (17), indicating that physiological postprandial concentrations of GLP-1 are sufficient to slow gastric emptying substantially

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