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Through improved glycemic control and promoting sustained weight loss, GLP-1 RAs enhance insulin sensitivity in adipose tissue and muscle, accompanied by reductions in pro-inflammatory cytokines (TNF, IL-1, IL-6) and elevations in adiponectin

However, it has been shown that GLP-1 secretion in response to mixed nutrient (carbohydrates, fats and proteins) intake is much higher than that secreted after glucose ingestion

Certainly, its important for individuals considering these medications to be aware of these considerations and discuss them with their healthcare provider

The approach to management of overweight and obesity is multi-pronged, and includes modification of physical activity and behaviour in addition to medical nutrition therapy

It supports lean muscle and keeps hunger manageable

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