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Weight gain is the second major side effect

Its important to recognize the broader effects and consider that patients may benefit even if they dont lose a significant amount of weight

However, many continue to market and sell these products

Scientists are also working to identify specific biological markers, genetic or metabolic traits, that could help determine which patients will benefit most from these treatments

cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act in concert to generate downstream signals resulting in increased insulin secretion 8

however, this endpoint serves more as a mechanistic clue than a direct clinical benefit (106)