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Results: Under short-term treatment, at 8.3 mmol/L glucose, BBR slightly induced insulin secretion with a gradually increasing second phase only, showing an increased number of ISGs fused without predocking to the plasma membrane

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Use in Specific Populations (8.6).] When JANUVIA was used in combination with insulin or insulin secretagogues (e.g., sulfonylurea), medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo used in combination with a sulfonylurea or with insulin

Was this a case of bad due diligence or a calculated decision to deprioritise a maturing market while pivoting to next-gen GLP-1 assets in the pipeline

Note that 8 mg at 5 mg/mL concentration requires drawing 160 units (1.6 mL), which exceeds a standard 1 mL insulin syringe

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