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We searched for approved generic competitors in the Orange Book to determine if the expected duration of protection for brand-name products had been cut short by early generic competition, and we used the FDAs Paragraph IV Certifications List (updated through the end of 2022) to identify patent challenges on brand-name products in the cohort

It has been granted GRAS (Generally Recognized as Safe) status by the FDA for use as a food supplement ingredient, though this is distinct from drug approval

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The safety profile of retatrutide was consistent with that of other incretin-based therapies

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