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This signaling includes stimulation of anorexigenic melanocortin and POMC/CART neurons and indirect inhibition of orexigenic NPY/AgRP in the hypothalamus

During the first few days, many patients experience mild gastrointestinal symptoms such as nausea or mild discomfort as their digestive system becomes accustomed to the medications action

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CNS Drugs 39 , 12011220 (2025)

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