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Soreness In animal studies, semaglutide was shown to increase the risk of certain thyroid tumors

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doi: 10.1038/srep14405 145 ZhaoL.ZhangF.DingX.WuG.LamY

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Although GLP-1s are generally well tolerated, with common side effects including gastrointestinal issues like nausea, vomiting, diarrhea and constipation, rare, more serious complications include issues like stomach paralysis, pancreatitis, bowel obstruction, kidney failure and thyroid cancer

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On the other hand, B-cell translocation gene 2 (BTG2) can upregulate Pdx1-induced insulin gene expression

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