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Dose escalation proceeds in steps to minimize nausea and gastrointestinal side effects while building toward the target maintenance dose

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Billon 2023 (ACS Chemical Biology) Preclinical in vivo, 15-28 days, C57BL/6J mice (n = 8-10 per group)

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If stomach pain persists despite these measures, discussing dose adjustment with the prescribing clinician may be appropriate

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Initial Dose : The starting dose is typically 0.25 mg once weekly

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It works by mimicking GLP-1, helping to slow digestion, regulate blood sugar, and reduce hunger

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This matters for three reasons

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