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One of the most extensive studies to date, performed by the Diabetes Prevention Program (DPP) and published in 2012, tested metformin in people with prediabetes

Investigators also highlighted the relative rise in popularity of semaglutide in recent years

Weight regain begins within weeks of stopping

Multiple studies show that high-fiber diets significantly increase postprandial GLP-1 levels

The biggest selling point of peptides is cognitive performance enhancement: Peptides can increase concentration and energy levels through improved mitochondrial efficiency, improve stress resistance (e.g., via cortisol modulation), and positively influence sleep and recovery

JAMA NetworkNCBI Endocrinology review (2025) on gastric/biliary/small bowel effects