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E.TerceF.et al (2017)

Additionally, the cardiac magnetic resonance substudy of the SUMMIT trial revealed that compared with placebo, tirzepatide treatment of obese HFpEF patients reduced the LV mass and paracardial adipose tissue volume, with the changes in the LV mass paralleling the degree of weight loss [166]

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Genetic identification of a neural circuit that suppresses appetite

However, due to danugliprons potential for drug-induced liver damage, 2025 Pfizer has announced that it is discontinuing development (Pfizer, 2025)