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- 21.05.2026 : 05.05.2026 Mounjaro

Seek urgent medical attention (contact 999, NHS 111, or attend A&E) if you experience: Black, tarry stools (melaena) may indicate upper gastrointestinal bleeding Bright red blood in or on stools, particularly if accompanied by dizziness, weakness, or rapid heartbeat Pale or clay-coloured stools with yellowing of skin or eyes (jaundice) potential biliary obstruction or liver dysfunction Severe abdominal pain with stool changes, especially if persistent or worsening Stop your GLP-1 medication and seek urgent medical assessment if you develop symptoms suggestive of pancreatitis (severe, persistent abdominal pain which may radiate to your back, with or without vomiting)

If you are managing anxiety on tirzepatide and considering additional medication, this interaction deserves attention during conversations with your prescriber

Some patients are focused primarily on weight loss, while others may be monitoring blood sugar, waist circumference, energy, or broader metabolic health

Tirzepatide users may lose up to 25% of their body weight, while semaglutide typically results in 1520% weight loss