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therefore, letrozole is considered first-line therapy

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In addition, there was a significant reduction in the renal arm of the composite microvascular outcome, involving new macroalbuminuria, sustained decline in estimated glomerular filtration rate or chronic renal replacement therapy

Wang J, Zhao D, Ding CZ, Guo F, Wu LN, Huang FJ, et al

Mice deficient for Irs2 [544], or transgenic mice deficient in CREB activity [546], are hyperglycemic due to severe -cell destruction and enhanced -cell apoptosis