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In intestinal L-cells and neurons of the NTS, a specific isoform of PC, PC1/3, is predominantly expressed and yields GLP-1, oxyntomodulin, and GLP-2 as the physiologically relevant products (134, 228, 238)

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130,131 Three clinical trials have been registered to evaluate the therapeutic effects of EVs in patients undergoing percutaneous coronary intervention (NCT04327635), postcoronary artery bypass grafting (NCT05669144), and nonischemic dilated cardiomyopathy (NCT05774509)

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