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But the real first scientific breakthrough that happened was in the early 70s

37 Wulffel, M.G., et al., Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial

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In the study by Jensen et al

Why Could GLP-1 Medications Cause Hair Loss