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Pendulum is led by Colleen Cutcliffe, a microbiome scientist and CEO with a PhD in biochemistry and microbiology from Johns Hopkins University

Though early work from companies like Vertex (Semma Tx acquisition) are focused on regeneration of pancreatic islets (for diabetes), Novo Nordisk recently inked a deal (including $75M upfront) with early-stage cell therapy player Aspect Biosystems

In vitro DDI studies detailed in clinical pharmacology and biopharmaceutics reviews were not included for exenatide and dulaglutide, but were included for liraglutide, semaglutide, and tirzepatide (Table 3).39,5658,139 All the investigated GLP-1 RAs and a dual GLP-1/GIP RA exhibited minimal inhibition or induction of CYP enzymes

Obesity, IR, chronic inflammation, oxidative stress, and diminished adipokine imbalance are all pathophysiological hallmarks of both diabetes and cancer, although unlike diabetic angiopathies, diabetes does not hasten cancer's development or progression [146]