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In a 40-week study, individuals with type 2 diabetes who weighed 213 lbs at the beginning of the study, people who took 0.5mg lost 9.3 lbs while people who took 1mg lost 12.8 lbs

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However, several observations do not support general BBB permeability, including the limited brain access observed with fluorescently labeled semaglutide in the present study, together with analogous results with GLP-1 (35) and liraglutide (8)