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In the SURMOUNT-5 trial, 89.3% of participants reached at least the 15 mg dose, indicating that most patients tolerate the dose escalation well

The detailed data processing procedure is shown in Figure 1

11 In the active-controlled trials that evaluated semaglutide as an add-on to 1 to 2 OADs (PIONEER 2 to 4), the proportion of patients that experienced at least 1 AE was ranged from 67% to 83% across treatment groups over 52 to 78 weeks
We should always think about how risk conversations can affect our patients emotionally

But if you consistently exercise at the same time you inject, be aware that the absorption spike may be faster than expected
Results: Among 475 randomized participants (211 [44%] women