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In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

DRUG OF THE DAY Tirzepatide Class: Dual GIP and GLP-1 Receptor Agonist MOA: Activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors enhances insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite improves blood sugar control and promotes weight loss

Dose de manuteno (faixa de pesquisa): 68 mg

Major drugmakers are investing in technologies to make GLP-1 pills more effective

The small-molecular drugs from various pharmacological classes and different phytoceuticals repurposed against PCOS are discussed along with their anti-PCOS activity mechanisms

In a new Journal of American Chemical Society study, Krishna Kumar, Martin Beinborn, and co-workers from Tufts University unveil the first unimolecular tetra-agonistspeptides that activate GLP-1R, GIPR, GcgR, and Y2R all at once