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9 GLP-1 agonists are contraindicated during pregnancy due to safety concerns, because they restrict foetal growth when given to experimental animals

GIP as a potential therapeutic target for atherosclerotic Cardiovascular Disease-A systematic review

Especially at concentrations of 10100 nM Liraglutide lead to a significant reduction in proliferation and DNA synthesis as observed in cell counting, MTS, 3-(4,5-di methylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) and [H]-thymidine incorporation assays [13, 20]

Clearly, these observations must be taken into account when prescribing DDP-4is, always with a view to a targeted therapy that is increasingly designed to meet the specific needs of the individual patient

90% of patients achieved more than 5% weight loss compared to 24% on placebo

This leads to increase in gastric volumes and putting the patients at increased risk of aspiration during sedation (107)