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At standard doses, most of the medication remains localized to vaginal tissue and produces minimal systemic hormone exposure
access is via clinical trial enrolment or regulated compounding
[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Umapathysivam M.M., Lee M.Y., Jones K.L., Annink C.E., Cousins C.E., Trahair L.G., Rayner C.K., Chapman M.J., Nauck M.A., Horowitz M., et al
"Unknown risk with no proven benefit" is the opposite of a good research design
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Arnold LM, Hudson JI, Keck PE, Auchenbach MB, Javaras KN, Hess EV
