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Results showed significant improvements in HbA1c levels and body weight with Tirzepatide treatment

I think what were seeing now is just the beginning of new types of weight loss drugs. Source: Stanford Medicine In a large, international clinical trial, people with obesity or overweight but not diabetes taking semaglutide for more than three years had a 20% lower risk of cardiovascular disease outcomes and lost an average of 9.4% of their body weight

The lack of mechanistic overlap also means you are not doubling up on the same side effects

Weeks 17 and beyond (optimization phase): If weight loss plateaus and you have not reached your goal, further dose increases (up to 15 mg weekly) may be appropriate

placebo: 4 mg dose group 9.1, 8 mg 9.2 and 12 mg 7.0), Week 12 (8 mg 8.2 and 12 mg 8.5), Week 16 (12 mg 9.2) and Week 24 (4 mg 8.3, 8 mg 9.4 and 12 mg 10.7

Because some of the anti-inflammatory action works independently of weight , even very small doses what clinicians call microdosing can calm the inflammatory signaling