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Prescription GLP-1 medications mimic the action of this hormone, but your body also produces GLP-1 naturally in response to factors such as the foods you eat, physical activity, and overall metabolic health

The legal and health risks of obtaining these compounds through grey-market channels are therefore considerable

doi:10.1007/s13300-019-0581-y 188

Older people who use this drug are at higher risk of this side effect

The main clinical consideration is volume status: if semaglutide causes significant nausea or vomiting, you could become dehydrated, which might necessitate holding metformin until hydration is restored