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A Phase IB study showed that it was well-tolerated and weight loss up to 6.4% was achieved over 12 weeks

The cost for obesity drugs with list prices in the $1,000 to $1,350 range per month before insurance is a major roadblock for many patients who could benefit from significant weight loss and the reduced potential for related health issues

Also there is the issue of prioritizing long term adherence versus short term control

SGLT2 inhibitors and renal outcomes in type 2 diabetes with or without renal impairment: A systematic review and meta-analysis

Off-Target Binding: Transporters, Serotonin Receptors, and Clinical Consequences SSRIs are relatively selective for SERT but show low-affinity interactions with other monoamine transporters (norepinephrine transporter (NET) and dopamine transporter (DAT)) and multiple serotonin receptor subtypes

A few are still years from clinical use but represent fundamentally new approaches