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GLP-1 also affects non-hunger related (hedonic) feeding by targeting brain areas involved in reward, motivation and addiction, such as the VTA, NAcc, lateral septum [701,741,744,745], and PVT [704]

Wegovy (semaglutide) and Zepbound (tirzepatide) work by mimicking hormones that signal fullness to your brain and slow how quickly food leaves your stomach. This dual effect eliminates the usual hunger signals you're accustomed to feeling

There is nothing wrong with this approach, as it follows the regulatory framework

It remains to be determined how GLP-1 confers its kidney benefits, as the only GLP-1 receptor that has been identified has limited expression in the kidney (8)

But there is a caveat