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We produced a once-weekly GLP-1 launched in 2014 called Trulicity

Mice (2035 g) were maintained in plastic ventilated cages in a pathogen-free environment (12 h/12 h light/dark cycle, 2124C) at Institut Pasteur de Lille, and had ad libitum access to water and food

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When activated, they improve the mobilization of stored fatty acids for use as fuel

Translocation of HMP-2/-catenin, and the GATA transcription factors, ELT-3 and PQM-1, are required for DTC-mediated longevity induction upon germline loss