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Description
We aimed to elucidate potential weight loss-independent mechanisms of GLP-1RA therapy in HFpEF following the administration of a low dosage of semaglutide that did not affect body mass, in a well-established preclinical model of cardiometabolic HFpEF
Nat Chem Biol 10:629631

What UAB Researchers Are Discovering The UAB article highlights that GLP-1 drugs dont just act in the gut they also have major effects in the brain

Key variants like GLP1R rs6923761, MC4R rs17782313, and FTO rs9939609 influence how strongly patients respond to semaglutide and how quickly they regain weight if therapy stops
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Am J Phys 271:E458E464 Deacon CF, Johnsen AH, Holst JJ (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

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