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Wegovy, a brand name of semaglutide, has been associated with these side effects: Nausea and vomiting Diarrhea or constipation Stomach pain or indigestion Decreased appetite leading to weight loss Fatigue and dizziness Increased heart rate Insomnia (difficulty sleeping) In rare cases, patients may also experience: Tremors and feelings of anxiety or nervousness

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It was first isolated, as an inhibitor of gastric acid secretion, from porcine small intestine crude extracts