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According to FDA labeling, frozen medication should not be used as freezing compromises the peptide structure and medication safety

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The results from these trials were positive and eventually led to Wegovy receiving FDA approval as a chronic weight management medication in June 2021

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For local injection site reactions potentially related to antibodies: Rotate injection sites systematically among recommended areas (abdomen, thigh, upper arm) Apply cold compresses before injection and warm compresses afterward if tolerated Consult with your healthcare provider before using any topical treatments, including corticosteroids, which should only be used short-term if recommended Ensure proper injection technique and medication storage Monitor for progression or systemic symptoms Mild local reactions that do not worsen over time may be managed conservatively with continued treatment and observation