glp-1 kidney outcomes news Updated evidence on cardiovascular and renal effects of receptor agonists and combination therapy with SGLT2 inhibitors and finerenone: a narrative review and perspectives | Cardiovascular Diabetology Kidney and Cardiovascular Outcomes Among

There are also GLP-1 tablet alternatives like the Wegovy tablet available if you would find it more suitable to take an oral pill rather than injecting

In October, Novo Nordisk announced Costco and Sam's Club would sell Wegovy and Ozempic for self-pay customers

It does this through several mechanisms

External resources PMC - Saving muscle while losing weight: strategies for GLP-1 related drugs American Urological Association - Semaglutide and urinary tract implications Annals of Internal Medicine - SGLT-2 inhibitors UTI comparison with GLP-1 agonists Diabetes Obesity Metabolism - Changes in lean body mass with GLP-1 therapies In case I do not see you, good afternoon, good evening, and good night

Our results are generally consistent in direction and magnitude with the existing clinical research, including trials showing reduced heavy alcohol consumption among those with obesity,14 reduced drinking in an experimental bar setting,12 and pharmacoepidemiological analyses showing that GLP-1 receptor agonists are associated with lower incidence and recurrence of alcohol use disorder,2 reduced need for tobacco use related care,5 lower incidence and relapse of cannabis use disorder,4 and reduced risk of opioid overdose in patients with opioid use disorders.8 Our results show that among people with a pre-existing SUD, GLP-1 receptor agonist use was associated with a reduced risk of several adverse clinical outcomes (SUD related emergency department visits, hospital admission, and mortality, drug overdose, and suicidal attempt or ideation)

Orforglipron may not surpass injectables in raw efficacy, but the potential for broader adoption through oral delivery is huge