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( 10.1016/S2213-8587(1830024-X) [DOI] [PubMed] [Google Scholar] 106.Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, Pedersen KB, Saugstrup T, Meier JJ

This dual-pathway interaction establishes a positive feedback loop: AMPK activation improves insulin sensitivity and reduces inflammation, which in turn supports the recovery of a beneficial microbial ecosystem

An increase in oxidative stress and ROS production play a role in mitochondrial DNA damage, respiratory impairment, and calcium imbalance, where all these symptoms of mitochondrial dysfunction are associated with AD