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While GLP-1RAs are known to affect pathways like -endorphin release and anti-inflammation, the precise mechanisms underlying their analgesic effects across different pain modalities are still not fully understood

However, several limitations warrant consideration when interpreting our findings

Neither timing has demonstrated superiority in clinical data

Based on current evidence, oral supplements have a stronger scientific foundation

Direct treatment of GLUTag L-cells with YM did not enhance GLP-1 secretion

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