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In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials

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A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness

[DOI] [PubMed] [Google Scholar] 34.He L, Wang J, Ping F, et al

Antagonistic hallmarks, which reflect the cellular responses to this damage