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Tirzepatide showed the greatest reduction in likelihood, with a 60% reduction, as seen in Figure 2

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doi: 10.1161/HYPERTENSIONAHA.111.175315

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Moreover, they show that metformin enhances the expression of the genes encoding the receptors for both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) in mouse islets and also increases the effects of GIP and GLP-1 on insulin secretion from beta cells