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observed significant between-group differences in hippocampal glutamate uptake between diabetic and control mice (F 2,14 = 10.84, p = 0.0014) wherein diabetic mice had significantly lower glutamate uptake.Reference Zanotto, Hansen and Galland 49 Following GLP-1 RA treatment, there was a significant reversal in glutamate uptake impairment wherein a 68.3% increase in glutamatergic metabolism was observed compared to diabetic rats that received negative control (p = 0.0005)