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patients in these groups should discuss their suitability with a clinician before participating in any trial Dietary habits high-fat or heavily spiced meals may exacerbate symptoms Diarrhoea in this context is a pharmacological side effect , not an allergic reaction or sign of serious harm in most cases

Over time, this can contribute to low energy intake, nutrient deficiencies, fatigue, weakness and muscle loss

RosenstockJAllisonDBirkenfeldALBlicherTMDeenadayalanSJacobsenJBet al

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These are potent pharmaceutical agents, not supplements, and medical oversight improves both safety and outcomes

Use of GLP-1 receptor agonists in early pregnancy and reproductive safety: A multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services