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Oral antihyperglycemic therapy with a SGLT2 inhibitor reverses cognitive impairments in elderly diabetics

There is no evidence on the effectiveness or safety of microdosing tirzepatide

Clinical response: Review dosage and consider slowing titration

He said: It is well established that better mental health tends to follow from better physical health and since the 1880s we have known that diabetes is associated with depression, although I think its unlikely that using GLP-1R agonists alone as treatments for depression or anxiety will work. Prof Eduard Vieta, a professor of psychiatry at the University of Barcelona and editor in chief of the European College of Neuropsychopharmacology journal, said: From a clinical perspective, these findings are reassuring regarding the psychiatric safety of GLP-1 receptor agonists and suggest a potential role not only in preventing worsening but also, possibly, in improving mental health outcomes

If you were on 2.5 to 5mg tirzepatide, start retatrutide at 1mg weekly

Some individuals on GLP-1s may reduce fluid intake because these medications delay gastric emptying, and patients may feel too full to drink more, says Marie Hiett, RD, a registered dietitian at Tufts Medicine Weight + WellnessStoneham in Massachusetts