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The FDAs decision was largely based on data from the SOUL trial, which included data from more than 9,000 patients who were randomized to oral Semaglutide or a placebo, & all patients had type 2 diabetes in addition to known ASCVD , CKD or both
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Subsequently, in vitro studies demonstrated that CGA-induced secretion of GLP-1 via enhancing cAMP levels in GLUTag cells
