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GLP-1 receptor agonists like semaglutide and tirzepatide work by slowing digestion and reducing appetite

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The autzhors searched MEDLINE, Embase, Cochrane Library, Scopus and Web of Science from inception to August 28, 2025 for randomised controlled trials (RCTs), non-randomised interventional studies and observational studies reporting weight outcomes after cessation of GLP-1RAs in adults with overweight or obesity

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