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Moreover, there have been reports of excessive off-label prescribing and misuse [28,29,30,31,32,33], and the GLP-1 RAs have become popular as a cosmetic weight loss drug by celebrities and are widely promoted on social media [34,35,36,37,38,39]

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By the late 1990s, the pieces were in place: GLP-1 was a validated target , and prototype therapeutic agents (exendin-4 and a few modified human GLP-1 analogs) were entering clinical testing

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10.1016/j.bcp.2021.114817 141 ZhuH.CaiH.WangX.ChenT.ZhenC.ZhangZ.et al (2022)

Understanding which GLP-1 formulations cause less nausea, and employing practical strategies to manage symptoms, can significantly improve treatment adherence and patient outcomes