soul trial oral semaglutide cardiovascular outcomes 2024 nejm results Reduces CV Events in T2DM – (NEJM, Mar 2025) Relevant for: cardiology, diabetology, nephrology, internal medicine 🧪 T2DM + ASCVD/CKD 💊 Oral semaglutide 14 mg vs placebo 📉 Effect of Oral Semaglutide on

Patients being treated with MET only entered a run-in period of 2-weeks duration, whereas patients pretreated with MET and one additional OAD entered a run-in treatment period of 6-weeks duration with MET monotherapy (dose of 1500 mg/day) and washout of the other agent

Micronutrients like zinc, magnesium, and B-vitamins become critical for recovery efficiency

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A separate 2025 cohort study from Weill Cornell found greater annualized hip bone loss in GLP-1RA users without diabetes compared to matched non-users

In SURPASS-4, Mounjaro lowered patient weight by 14 pounds (5 mg), 20 pounds (10 mg), and 23 pounds (15 mg) compared to a gain of 4 pounds with insulin glargine

How Dairy Products Might Influence These Side Effects Since dairy can affect digestion in various ways, understanding how it might interact with semaglutides side effects is useful