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Yes, in many cases you can with caution and different expectations
One used a diphtheria toxin-inducible -cell KO of Gcg and this mouse had a small impairment of age-induced IP glucose tolerance (227)

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In these situations, especially when GLP-1 use is part of a patients treatment regimen, transit effects often explain the discrepancy

More than half of the participants receiving tirzepatide lost 25% or more of their body weight during the trial period

Some patients report emotional changes, fatigue, or irritability during appetite and metabolic adjustments