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Eating during the day inhibits bone resorption but increases bone resorption at night, and this daytime suppression is eliminated by fasting, further affirming the role of the gut hormones in the control of bone homeostasis

Schroeder R, Harrison TD, McGraw SL

Results Dosing of mGIPR-Ab or mGIPR-Ab/GLP-1 produces weight loss To investigate the role of GIPR in energy balance in the CNS, male mice that were fed a high-fat diet (HFD) were administered intracerebroventricular (ICV) injections of varying doses of a fully human anti-human GIPR antibody that cross-reacts with mouse GIPR (mGIPR-Ab)

These changes compound, especially in patients with pre-existing postural weakness or sedentary lifestyles

& Sssmuth, R

In intestinal L-cells - concentrated in the distal ileum and colon - PC1/3 processes proglucagon into GLP-1 , GLP-2, glicentin, and oxyntomodulin