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Although obese mice are not identical to obese humans, the results are highly suggestive

A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation

As the dosage reaches the therapeutic level, you are more likely to notice a significant reduction in hunger

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In Trial 1, patients 12 years and older who were able to self-report their hunger (n=110), recorded their daily maximal hunger in a diary, which was then assessed by the Daily Hunger Questionnaire Item 2