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Genetic factors, such as nonsynonymous single-nucleotide polymorphisms (SNPs) in the patatin-like phospholipase domaincontaining protein 3 (PNPLA3) gene, further influence the severity of liver damage

Further, experimental data suggest that the pro-survival action of GLP-1RAs may also be mediated by the Akt-dependent stimulation of the mTORC1/S6K1 pathway, the activation of which is dependent upon the IGF-1R, as observed in rodent islet cells (44)

Overall, these results demonstrate that GLP-1 RAs may exert their therapeutic effects through multiple mechanisms in MASH treatment

If you are already on a GLP-1 medication from another provider, you can maintain your current dose with documentation of your prior prescription
GLP-1 medications are a new dimension of opportunity and possibility for pediatric weight management

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