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Additional markers to consider: oxidative stress markers (8-isoprostane, malondialdehyde), inflammatory markers (hsCRP, IL-6), liver function tests

Simple, because its purely a matter of energy balance - calories in vs

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Patients with higher genetic predisposition for GLP-1 receptor responsiveness may experience greater appetite suppression at lower doses, potentially shortening their 2mg pen duration or requiring slower escalation

In addition, in T1DM, DPP-4 inhibitors as add-on to insulin therapy can reduce the daily insulin requirements 6