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Published research on RS2 has examined potential benefits for insulin sensitivity and fat metabolism at clinical dosages typically ranging from 15 to 40 grams daily
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PubMed Qin B et al
Which Drug Is Generally Most Potent for Weight Loss

Think of Zepbound as using two complementary approaches simultaneously rather than relying on one very effective approach
It is very nuanced for the individual, but I do think it's a really good idea that we are measuring serum estradiol