glp-1 agonist. Receptor Agonists and Research to Treat Overeating and Substance Use Disorders The Buzz Around GLP-1 Agonists

Description

References Meier JJ

They are modifications of the hormone GLP-1, which is produced by the gut during a meal

Previous serious hypersensitivity reactions, current pregnancy (especially for weight-loss indications), active pancreatitis and severe gastroparesis generally contraindicate use

Weight loss occurs in a dose-dependent way and exhibits a biphasic pattern: an initial quick phase induced by decreased calorie intake, followed by a slower phase indicative of metabolic tolerance and enduring behavioural modifications

Because their peaks are lower and persistent, some patients find them more tolerable (less severe nausea spikes), though they still cause significant GI side effects in many