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METHODS GLP-1RAs decrease the cholesterol level and regulate the expression of cholesterol metabolism-associated genes in HepG2 cells treated with PA In HepG2 cells, treatment with PA significantly increased cholesterol levels in both cell lysates and culture supernatants

Wegovy (Semaglutide)- a once-weekly subcutaneous injection given in the back of the arm, the thigh, or the abdomen

PMID: 34239993

Medical writing support was provided by Aarti Shah and Nicole Westerholm of AXON Communications (funded by Novo Nordisk A/S)

This approach represents a significant shift in how we think about sustainable weight management and metabolic health support

This makes it appropriate for patients with cardiovascular concerns, anxiety, or a history that contraindicates stimulant use