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At 12 months post-GLP-1RAinitiation, significant improvements were observed in HbA1c, body weight, and body fat percentage ( Table 2 )

Patient enrollment in clinical studies is also based mainly on baseline A1C, and treatment of a comparator is sometimes chosen unrelated to its pathophysiologic effect on hyperglycemia

The role of PYY as a satiety hormone has been debated, as several independent research groups did not reproduce the anorectic effect in humans reported in the original study by Batterham et al

Participants eating traditional sized meals (500 to 700 calories) experienced nausea rates of 41%

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